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The available drugs against coronavirus disease 2019 (COVOD-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are limited. This study aimed to identify ginger-derived compounds that might neutralize SARS-CoV-2 and prevent its entry into host cells. Ring compounds of ginger were screened against spike (S) protein of alpha, beta, gamma, and delta variants of SARS-CoV-2. The S protein FASTA sequence was retrieved from Global Initiative on Sharing Avian Influenza Data (GISAID) and converted into ".pdb” format using Open Babel tool. A total of 306 compounds were identified from ginger through food and phyto-databases. Out of those, 38 ring compounds were subjected to docking analysis using CB Dock online program which implies AutoDock Vina for docking. The Vina score was recorded, which reflects the affinity between ligands and receptors. Further, the Protein Ligand Interaction Profiler (PLIP) program for detecting the type of interaction between ligand-receptor was used. SwissADME was used to compute druglikeness parameters and pharmacokinetics characteristics. Furthermore, energy minimization was performed by using Swiss PDB Viewer (SPDBV) and energy after minimization was recorded. Molecular dynamic simulation was performed to find the stability of protein-ligand complex and root-mean-square deviation (RMSD) as well as root-mean-square fluctuation (RMSF) were calculated and recorded by using myPresto v5.0. Our study suggested that 17 out of 38 ring compounds of ginger were very likely to bind the S protein of SARS-CoV-2. Seventeen out of 38 ring compounds showed high affinity of binding with S protein of alpha, beta, gamma, and delta variants of SARS-CoV-2. The RMSD showed the stability of the complex was parallel to the S protein monomer. These computer-aided predictions give an insight into the possibility of ginger ring compounds as potential anti-SARS-CoV-2 worthy of in vitro investigations. © 2023, School of Medicine, Universitas Syiah Kuala. All rights reserved.
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This paper investigates whether the COVID-19 cases and death rates affect the dynamic correlation of corporate-government bond yields. Therefore, this study uses the daily corporate bond data with different ratings of bonds along with the COVID-19 data at both the US and global levels. Using the quantile regression approach, it produces the following results. First, the impact of daily cases differs from that of death rates both locally and globally. Second, the impact of local cases and death cases on the government-AAA yields correlation at a given quantile tends to reverse when the BBB bonds are used in the analysis. Third, global death rates significantly affect the correlation series the most at the higher quantiles. Lastly, AAA-rated bonds show higher sensitivity to COVID-19 cases and death rates than BBB-rated bonds. This finding indicates that relatively high-quality bonds are more susceptible to the pandemic period and thus calls for careful evaluation of assets included in investors' portfolios. This study assumes that local COVID-19 data provide a better implication for constructing bond portfolios than global data. That is, their economic impact depends on the rating of the bond and tends to vary more across correlation quantiles. © Ahmad Alkhataybeh, Mobeen Ur Rehman, Ghaith El-Nader, Abedalrazaq Alrababa'a, Mohammad Alomari, 2022.
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Purpose Fear of COVID-19 is a new workplace hazard that has made drastic changes at workplaces globally. Based on the conservation of resource (COR) theory, this research investigates the relationship between fear of COVID-19 and employee engagement. Furthermore, this study examines the moderating role of emotional stability in the relationship between fear of COVID-19 and employee engagement. Design/methodology/approach Data were collected using self-administrated questionnaires from bank employees located in different cities of Pakistan. PROCESS macro by Hayes et al. (2017) was used to analyze 267 valid responses. Findings Consistent with the hypotheses of this study, fear of COVID-19 was negatively associated with employee engagement. In addition, the moderating role of emotional stability was confirmed in the relationship between fear of COVID-19 and employee engagement. The findings of this study support the notion that fear of COVID-19 can be considered a workplace stressor that affects employee engagement. By contrast, emotional stability acts as a personal resource with a buffering effect. Research limitations/implications This study investigates only the moderating mechanism in the relationship between fear of COVID-19 and work engagement. A self-reported questionnaire was used to collect the data. For future studies, other sources can be used to reflect the actual situation. Originality/value This study is currently relevant because of the sudden occurrence of the COVID-19 pandemic that has mentally and emotionally challenged the service employees. Unlike most prior studies, which investigated the impact of fear of COVID-19 on the health sector professionals, this study investigated the impact on the bank employees. Moreover, this study is among the first to provide insights on the role of employee's personality to maintain positive work attitudes during uncertain circumstances from COVID-19.
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Background: Around one and half years ago in the December of 2019 a flu like disease emerged in the city Wuhan located in China. This was termed by WHO as a global pandemic due to its rapid widespread. Aim: To compare the efficacy of high dose dexamethasone (8 mgx tds) vs low dose methylprednisoslone (100 mgx bd) therapy for two weeks, in resolution of acute inflammatory markers in patients with covid pneumonia. Study Design: Quasi experimental study. Methodology: Patients (n=72) with an age range of 18-70 years with Covid 19 PCR positive having Covid associated pneumonia were enrolled. Group 1 containing 36 patients receiving high dose dexamethasone (8 mgx TDS) and group 2 with 36 participants receiving low dose methylprednisolone (100 mgx BD). Inflammatory markers (CRP, ESR and Ferritin) were recorded on Day 1 (T1) on day 7 (T2) and day 14 (T3). Patients who required ventillatory support and those who died was also recorded.All this information was recorded on Performa. Data was analyzed using SPSS version 26. Results: Mean age of the patients was 50.11±11.7 years. When we compared the inflammatory markers among group 1 and group 2 at T1, T2 and T3 no statistically significant difference was obtained. Conclusion: It was concluded that high dose dexamethasone and low dose methylprednisoslone therapy for two weeks were equally effective in resolution of acute inflammatory markers in patients with covid pneumonia.
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The recent pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has increased the global concern over its transmission and prevention. Since there was an incontrovertible perception that environmental conditions might affect the spread of SARS-CoV-2, we analyzed the environmental variables impact on SARS-CoV-2 transmission in Pakistan. Our analytical study revealed that when the temperature remained high for consecutive 10 to 15 days, a significant decrease is witnessed in the forthcoming week in the COVID-19 cases. We found that a persistent high ambient temperature of 36 °C and above is detrimental to SARS-CoV-2 transmission and has paused the community spread of COVID-19 in Pakistan. Importantly, during the fall period of SARS-CoV-2, a high relative humidity of 63-72% was noted that showed a positive role in COVID-19 inhibition. Hence, the community spread of SARS-CoV-2 was paused by the warm humid climate and the ambient temperature was the yardstick in turning down the epidemic in Pakistan.
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In this article, a brief biological structure and some basic properties of COVID-19 are described. A classical integer order model is modified and converted into a fractional order model with ξ as order of the fractional derivative. Moreover, a valued structure preserving the numerical design, coined as Grunwald–Letnikov non-standard finite difference scheme, is developed for the fractional COVID-19 model. Taking into account the importance of the positivity and boundedness of the state variables, some productive results have been proved to ensure these essential features. Stability of the model at a corona free and a corona existing equilibrium points is investigated on the basis of Eigen values. The Routh–Hurwitz criterion is applied for the local stability analysis. An appropriate example with fitted and estimated set of parametric values is presented for the simulations. Graphical solutions are displayed for the chosen values of ξ (fractional order of the derivatives). The role of quarantined policy is also determined gradually to highlight its significance and relevancy in controlling infectious diseases. In the end, outcomes of the study are presented. © 2022 Tech Science Press. All rights reserved.
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The novel coronavirus disease-2019 (COVID-19) is an ongoing viral infection and currently, limited vaccines with no post-market safety data or repurposed drugs are available to combat this contagious viral disease. Kabasura Kudineer, an official polyherbal Siddha medicine containing numerous herbal ingredients, is being practiced primarily in southern parts of India in the management of COVID-19 pandemic for boosting the respiratory system and treating fever with flu-like symptoms. The present study is carried out to scientifically validate the traditional claim and to confirm identity, quality and purity of marketed Kabasura Kudineer polyherbal formulations in India. Kabasura Kudineer Chooranam manufactured by two different manufacturers was procured from New Delhi, India. The physicochemical characterization of the samples was carried out in accordance with the standards laid down by Indian Pharmacopoeia (IP) 2018. HPTLC profiling of key ingredients including Kalmegh (Andrographis paniculata), Guduchi (Tinospora cordifolia), Pippali (Piper longum), Vasaka (Adhatoda vasica) and Lavang (Syzygium aromaticum) were also carried out in accordance with IP 2018 monographs. The chromatographic analysis showed the presence of all major ingredients in both the marketed preparations and all the physicochemical properties were also found comparable among preparations. Our findings may enhance the global acceptance of Siddha medicines practiced widely in India and also used for laying down the pharmacopoeial standards of Kabasura Kudineer Chooranam.
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Background: The whole world is facing one of the biggest health related disaster (COVID-19) of the century. Aim: To identify age and gender-based differences in Covid-19 clinical features and its management among patients at government hospitals, Pakistan. Study design: Cross-sectional study. Methodology: This study with enrolled subjects (n=206) was carried out after ethical review committee's (ERC) approval at Life Diabetes Centre, Gujrat and CMH Kharian Medical College (CKMC), over a period of 3 months, Kharian-Pakistan. Both male and female medical subjects were enrolled. Statistical analysis: Data was analyzed by SPSS software, version 17. Parameters like age, gender and treatment taken were presented as frequency. Chi square was applied to see the correlation with p-value <0.05 as significant. Results: Total 206 patients were randomly selected, 89 male and 117 females. Among 206, patients (n=133) showed symptoms while rest of the patients (73) remained asymptomatic. There was no association of age and gender with COVID-19 symptoms having P-value greater than 0.05. There was a significant association between treatments given was significantly related with age having P-value (0.006*). Conclusion: We concluded that there was no strong association between age and gender-based differences in Covid-19 clinical features;this could be due to small sample size.
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This paper focuses on policy development in a Higher Education context and provides a model fur ensuring sustainable educational practice in TNE partnerships under disruptive situations. The focal point of policy initiation and development was the Covid-19 virus outbreak in China and the ensuing impact on program delivery and assessment. The development takes a novel approach by applying a combination of commercial scenario planning and crisis management techniques to create a coherent and prescriptive educational policy for staff operating in a Transnational Education (TNE) partnership based on the fly-in, fly-out (FIFO) faculty model. It demonstrates the application of these management tools and describes how, through careful analysis and planning, disruption to student learning, teaching and assessment can be minimized.
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The COVID-19 pandemic outbreak and the lockdown and social distancing strategies adopted to contain it have drastically affected our daily lives and the routine businesses. Provision of educational services in a continuous and useful manner in such circumstances is a massive challenge and requires innovative methods. Effective assessment and feedback play a pivotal role in traditional teaching and learning approaches and it is of even more vital importance in disruptive conditions. This paper discusses different assessment and feedback techniques in the online delivery of higher education courses in kickdown scenarios. The effectiveness of these approaches is evaluated through qualitative and quantitative study of student and staff feedback for an engineering course being delivered as part of a transnational education (TNE) program. In the light of the results, recommendations are made to improve the assessment and feedback activities in disruptive circumstances.
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Purpose: The coronavirus disease 2019 (COVID-19) pandemic has affected the global economy and, thus, the global construction industry. This paper aims to study the impact of COVID-19 on construction project performance in the United Arab Emirates (UAE). Design/methodology/approach: This study adopted a qualitative and exploratory approach to investigate the impact of COVID-19 and its policies on project performance in the UAE construction industry in critical areas of the project management body of knowledge (e.g. schedule, cost, resources and contracts). Semi-structured interview questions were asked from ten construction professional to obtain valuable insights into the pandemic’s effects on the UAE construction industry and the effectiveness of policies implemented to rectify the damage and identify the industry’s new normal. Findings: The findings indicate that the construction industry faced several challenges such as schedule delays, disrupted cashflows, delayed permits, approvals and inspections, travel restrictions, serious health and safety concerns, material and equipment shortages, among others which hindered the timely delivery of construction projects. It also indicates that efforts made by the government institutions and the construction industry of the UAE such as economic support programs, digitization of processes, fee and fine waivers, health facilities, among other statutory relaxations proved effective in supporting the construction industry against the adverse effects of the pandemic. Research limitations/implications: The research findings are limited to the literature review and ten semi-structured interviews seeking an expert’s opinion from industry professionals working in the UAE construction industry. The research team did not get access to project documents, contracts and project progress reports which may be required to validate the interview findings, and to perform an in-depth analysis quantifying the impact of COVID 19 on construction projects performance, which is a limitation of this research. Practical implications: The implication is that, owing to the imposed lockdowns and strict precautionary measures to curb the rapid spread of the pandemic, smooth execution of the construction project across the country was affected. The government institutions and stakeholders of the construction projects introduced and implemented various techniques and solutions which effectively handled the implications of the COVID-19 pandemic on the construction industry of the UAE. Originality/value: This study has identified the challenges faced by the construction industry of the UAE in the context of the management of project schedule, project cost, construction contracts, health and safety of construction employees and other related aspects of the construction projects. This study also identified the techniques and solutions adopted by various public and private institutions of the country and their implications on construction projects. Therefore, this study provides guidelines for policymakers and future research studies alike. © 2021, Emerald Publishing Limited.
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Context: RNA viruses exhibit an extraordinary ability to evolve in a changing environment and to switch from animal hosts to humans. The ongoing COVID-19 pandemic, recognized as a respiratory disease, is an example of zoonotic transmission of the RNA virus known as SARS-CoV-2. The development and regulatory approval of a vaccine against SARS-CoV-2 pose multiple preventive and therapeutic challenges, especially during an ongoing pandemic. Objective: The review intended to examine the challenges and recent achievements in the development of vaccine candidates against COVID-19. Design: The research team performed a literature review, searching relevant and up to date information from the literature. The sources of data included Google Scholar, PubMed, NCBI, and Yahoo. The search terms used were COVID-19 challenges, SARS-CoV-2 prospective challenges, RNA viruses adoptability, host switching by RNA viruses, COVID-19 vaccines. Setting: The study took place at the digital libraries of contributing institutions. The data was combined, selected for further analysis and manuscript preparation at King Abdulaziz University. Results: RNA viruses with high rate of genome alterations and evolution have better chances to survive in the adverse environmental conditions by adopting the alternate host species. The recent epidemics such as SARS, MERS, and COVID-19 are examples of zoonotic transmission of RNA viruses from animal species to the humans. However, the mechanisms involved in the switching-on to new host species need further investigations to control the zoonotic transmissions in near future. As of April 2020, 115 candidate vaccines were being evaluated;78 of them had been found to be active, and a few of them are in Phase I trials. In the development of different types of vaccine candidates against COVID-19, multiple international pharmaceutical and biotechnology companies are involved. Conclusions: Emerging and re-emerging pathogenic RNA viruses pose a serious threat to human health. Little is known about the human-host adoptive mechanism for zoonotic transmission. Deep insights into the molecular mechanism responsible for the switching of animal or bird viruses to humans could provide target molecules or events to prevent such transmissions in the near future. Fast development and approval of efficacious and safe vaccines is key to the effort to provide preventive measures against COVID-19 and future viruses. However, the development and availability of a vaccine candidate is a time-consuming process and often can't be completed during an epidemic. Currently, several types of vaccines are under development, and most of them won't realistically be available in time for the present COVID-19 pandemic.